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J Scott Daniels Selected Research

ML253

1/2013Discovery of a selective M₄ positive allosteric modulator based on the 3-amino-thieno[2,3-b]pyridine-2-carboxamide scaffold: development of ML253, a potent and brain penetrant compound that is active in a preclinical model of schizophrenia.

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J Scott Daniels Research Topics

Disease

13Schizophrenia (Dementia Praecox)
03/2016 - 02/2012
6Catalepsy
01/2016 - 11/2011
6Parkinson Disease (Parkinson's Disease)
01/2016 - 12/2011
6Neoplasms (Cancer)
10/2015 - 04/2006
4Alzheimer Disease (Alzheimer's Disease)
01/2017 - 06/2012
3Inflammation (Inflammations)
11/2018 - 04/2006
3Psychotic Disorders (Schizoaffective Disorder)
01/2017 - 07/2014
2Pain (Aches)
05/2019 - 01/2019
2Autistic Disorder (Autism)
01/2016 - 09/2012
2Fragile X Syndrome (Martin Bell Syndrome)
01/2016 - 09/2012
2Central Nervous System Diseases (CNS Diseases)
11/2015 - 09/2013
2Infections
11/2015 - 09/2014
2Human Influenza (Influenza)
12/2014 - 09/2014
2Hypoxia (Hypoxemia)
04/2013 - 11/2004
2Multiple Myeloma
04/2006 - 06/2005
1Delirium
11/2019
1Obesity
10/2019
1Insulin Resistance
10/2019
1Rett Syndrome (Rett's Disorder)
01/2017
1Dementia (Dementias)
01/2017
1Neurodevelopmental Disorders
01/2017
1Cardiovascular Diseases (Cardiovascular Disease)
01/2017
1Mental Disorders (Mental Disorder)
01/2017
1Parkinsonian Disorders (Parkinsonism)
11/2016
1Dyskinesias (Dyskinesia)
01/2016
1Visceral Leishmaniasis (Kala Azar)
11/2015
1Chagas Disease (American Trypanosomiasis)
11/2015
1Leukemia
07/2015
1Brain Diseases (Brain Disorder)
02/2015
1Seizures (Absence Seizure)
09/2013
1Communicable Diseases (Infectious Diseases)
08/2013
1Cocaine-Related Disorders (Cocaine Addiction)
08/2013
1Glioblastoma (Glioblastoma Multiforme)
03/2013
1Hypertension (High Blood Pressure)
01/2013
1Diabetes Mellitus
01/2013

Drug/Important Bio-Agent (IBA)

9Metabotropic Glutamate Receptors (Metabotropic Glutamate Receptor)IBA
01/2016 - 02/2012
6Haloperidol (Haldol)FDA LinkGeneric
01/2016 - 11/2011
4Muscarinic Receptors (Muscarinic Acetylcholine Receptor)IBA
01/2017 - 06/2012
31-dodecylpyridoxal (PLD)IBA
12/2014 - 09/2010
3Metabotropic Glutamate 5 ReceptorIBA
07/2014 - 10/2013
3Oxygen (Dioxygen)IBA
04/2013 - 11/2004
3Bortezomib (Velcade)FDA Link
12/2006 - 06/2005
2Morphine (MS Contin)FDA LinkGeneric
05/2019 - 01/2019
2VU0466551IBA
05/2019 - 01/2019
2Analgesics (Analgesic Drugs)IBA
05/2019 - 01/2019
2Biomarkers (Surrogate Marker)IBA
01/2017 - 04/2006
2Glutamate Receptors (Glutamate Receptor)IBA
03/2016 - 05/2015
2N-Methylaspartate (NMDA)IBA
03/2016 - 05/2015
2metabotropic glutamate receptor 4IBA
01/2016 - 01/2016
2Levodopa (L Dopa)FDA LinkGeneric
01/2016 - 02/2012
2Proteins (Proteins, Gene)FDA Link
01/2016 - 07/2015
2Pharmaceutical PreparationsIBA
11/2015 - 03/2015
2EnzymesIBA
11/2015 - 11/2004
2Amphetamine (Amfetamine)FDA LinkGeneric
03/2015 - 07/2014
2Tirapazamine (SR 4233)IBA
10/2007 - 11/2004
2DNA (Deoxyribonucleic Acid)IBA
10/2007 - 11/2004
2Proteasome InhibitorsIBA
04/2006 - 06/2005
2Boronic AcidsIBA
04/2006 - 06/2005
1Psychotropic Drugs (Psychoactive Drugs)IBA
11/2019
1Opioid Analgesics (Opioids)IBA
01/2019
1Opioid Receptors (Opioid Receptor)IBA
01/2019
12-(aminomethyl)phenolIBA
11/2018
1Methyl-CpG-Binding Protein 2IBA
01/2017
11- Methyl- 4- phenyl- 1,2,3,6- tetrahydropyridine (MPTP)IBA
11/2016
1Clozapine (Clozaril)FDA LinkGeneric
03/2016
15- amino- 3,4- dimethyl- N- (4- ((trifluoromethyl)sulfonyl)benzyl)thieno(2,3- c)pyridazine- 6- carboxamideIBA
03/2016
1Dizocilpine Maleate (Dizocilpine)IBA
03/2016
1Hypnotics and Sedatives (Sedatives)IBA
03/2016
1Therapeutic UsesIBA
01/2016
1Antiparasitic Agents (Antiparasitics)IBA
11/2015
1AzolesIBA
11/2015
1Cadherins (E-Cadherin)IBA
10/2015
1piperidineIBA
07/2015
1VU0409551IBA
06/2015
1Exenatide (Byetta)FDA Link
12/2014
1VU0468809IBA
12/2014
1Antiviral Agents (Antivirals)IBA
12/2014
1Phospholipase DIBA
09/2014
1Glutamic Acid (Glutamate)FDA Link
07/2014
1Cytochrome P-450 CYP3AIBA
12/2013
1Cytochrome P-450 Enzyme System (Cytochrome P450)IBA
09/2013
1Cocaine (Cocaine HCl)IBA
08/2013
1VU0463841IBA
08/2013
1ProdrugsIBA
04/2013
1Oxidoreductases (Dehydrogenase)IBA
04/2013
13,4- difluoro- N- (2- (1- (3- fluorophenyl)- 4- oxo- 1,3,8- triazaspiro(4.5)decan- 8- yl)ethyl)benzamideIBA
03/2013
1ML299IBA
03/2013
1decaneIBA
03/2013
1ProstaglandinsIBA
01/2013
1Prostaglandins EIBA
01/2013
1ML253IBA
01/2013
1benzocycloheptapyridineIBA
01/2013
1compound 17IBA
01/2013
1Oxidopamine (6 Hydroxydopamine)IBA
02/2012
1N-(3-chlorophenyl)picolinamideIBA
02/2012
1Adenosine (Adenocard)FDA LinkGeneric
02/2012
12- (2- furanyl)- 7- (2- (4- (4- (2- methoxyethoxy)phenyl)- 1- piperazinyl)ethyl)- 7H- pyrazolo(4,3- e)(1,2,4)triazolo(1,5- c)pyrimidine- 5- amineIBA
02/2012
1T-Type Calcium Channels (T-Type Calcium Channel)IBA
12/2011

Therapy/Procedure

6Therapeutics
10/2019 - 06/2005
2Polypharmacy
11/2019 - 01/2017